Frank L Meyskens Selected Research

Eflornithine (Ornidyl)

1/2014	Chemoprevention of prostate cancer with the polyamine synthesis inhibitor difluoromethylornithine.
10/2012	Role of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO) + sulindac for the prevention of sporadic colorectal adenomas.
10/2010	Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients.
11/2009	Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention.
3/2009	Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas.
2/2009	Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation.
12/2008	Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.
6/2008	Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial.
2/2007	Development and characteristics of a human cell assay for screening agents for melanoma prevention.

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Frank L Meyskens Research Topics

Disease

44	Neoplasms (Cancer) 03/2020 - 11/2002
35	Melanoma (Melanoma, Malignant) 01/2022 - 01/2002
13	Prostatic Neoplasms (Prostate Cancer) 12/2016 - 01/2009
12	Adenoma (Adenomas) 01/2020 - 10/2003
11	Carcinogenesis 11/2020 - 10/2003
6	Breast Neoplasms (Breast Cancer) 01/2019 - 07/2013
5	Skin Neoplasms (Skin Cancer) 01/2022 - 01/2003
5	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 10/2003
4	Polyps 01/2020 - 02/2009
3	Neoplasm Metastasis (Metastasis) 01/2019 - 09/2009
3	Inflammation (Inflammations) 10/2017 - 02/2009
3	Ototoxicity 10/2010 - 12/2008
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2018 - 10/2017
2	Actinic Keratosis 12/2018 - 12/2004
2	Hypoxia (Hypoxemia) 01/2018 - 02/2007
2	Hyperplasia 10/2017 - 01/2016
2	Arthralgia (Joint Pain) 10/2015 - 06/2015
2	Aberrant Crypt Foci 03/2015 - 03/2011
2	Oral Leukoplakia 05/2013 - 10/2003
2	Cardiovascular Diseases (Cardiovascular Disease) 03/2011 - 12/2004
2	Adenomatous Polyps 12/2008 - 06/2008
1	Edema (Dropsy) 01/2022
1	Coma (Comas) 01/2019
1	Carcinoma (Carcinomatosis) 01/2019
1	Premature Menopause 01/2019
1	Cataract (Cataracts) 12/2016
1	Macular Degeneration (Age-Related Maculopathy) 12/2016
1	Alzheimer Disease (Alzheimer's Disease) 12/2016

Drug/Important Bio-Agent (IBA)

14	Biomarkers (Surrogate Marker)IBA 09/2015 - 07/2003
13	Pharmaceutical PreparationsIBA 01/2022 - 01/2002
9	Eflornithine (Ornidyl)FDA Link 01/2014 - 02/2007
8	SeleniumIBA 12/2016 - 01/2009
8	Vitamin E FDA LinkGeneric 12/2016 - 01/2009
8	PolyaminesIBA 01/2014 - 10/2004
7	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 06/2003
7	Sulindac (Copal)FDA LinkGeneric 10/2010 - 06/2008
6	Melanins (Melanin)IBA 01/2016 - 06/2003
6	Biological ProductsIBA 01/2016 - 12/2004
5	EnzymesIBA 01/2018 - 03/2009
5	Proteins (Proteins, Gene)FDA Link 04/2016 - 04/2004
5	EndonucleasesIBA 11/2014 - 12/2005
5	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/2014 - 06/2008
5	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 12/2008 - 02/2004
4	MetalsIBA 01/2022 - 05/2008
4	Transcription Factors (Transcription Factor)IBA 01/2018 - 01/2005
3	Carvedilol (Coreg)FDA LinkGeneric 01/2022 - 10/2017
3	Oxygen (Dioxygen)IBA 01/2019 - 06/2003
3	CarcinogensIBA 10/2017 - 07/2008
3	Prostate-Specific Antigen (Semenogelase)IBA 10/2014 - 01/2009
3	ResveratrolIBA 12/2008 - 01/2005
2	Pyrimidine DimersIBA 01/2022 - 10/2017
2	Estrogen ReceptorsIBA 03/2020 - 01/2019
2	Hormones (Hormone)IBA 03/2020 - 01/2015
2	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 10/2016
2	AntioxidantsIBA 01/2019 - 01/2005
2	Goserelin (Zoladex)FDA Link 01/2019 - 01/2015
2	Superoxides (Superoxide)IBA 01/2018 - 04/2016
2	Phosphotransferases (Kinase)IBA 01/2018 - 08/2010
2	Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA 01/2016 - 01/2012
2	taxaneIBA 10/2015 - 07/2013
2	Aromatase InhibitorsIBA 10/2015 - 06/2015
2	Finasteride (Propecia)FDA LinkGeneric 08/2014 - 09/2012
2	A 17 (A-17)IBA 03/2014 - 12/2004
2	PutrescineIBA 01/2014 - 06/2007
2	OrnithineIBA 01/2014 - 10/2010
2	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 01/2014 - 11/2009
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2013 - 12/2008
2	matrigelIBA 08/2012 - 12/2008
2	CalciumIBA 12/2011 - 10/2003
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 11/2009 - 03/2009
2	Vitamin A (Retinol)FDA LinkGeneric 12/2008 - 12/2004
2	PlacebosIBA 12/2008 - 06/2008
2	Disulfiram (Antabuse)FDA Link 12/2004 - 01/2002
1	carboxypolymethyleneIBA 01/2022
1	CopperIBA 01/2022
1	SaltsIBA 01/2022
1	IonophoresIBA 01/2022
1	Coordination ComplexesIBA 01/2022
1	cupric chloride (copper(II) chloride)FDA Link 01/2022
1	3-hydroxy-2-methyl-4H-pyran-4-thioneIBA 01/2022
1	Insulin-Like PeptidesIBA 03/2020
1	SteroidsIBA 03/2020
1	Estrogens (Estrogen)FDA Link 03/2020
1	NitrogenIBA 01/2019
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2019
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2019
1	AcidsIBA 12/2018
1	CatalaseIBA 01/2018
1	NADP (NADPH)IBA 01/2018
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2018
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2018
1	Mitogen-Activated Protein KinasesIBA 01/2018
1	Epidermal Growth Factor (EGF)IBA 10/2017
1	Interleukin-6 (Interleukin 6)IBA 10/2017
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 04/2016

Therapy/Procedure

21	Chemoprevention 11/2020 - 11/2002
9	Therapeutics 01/2018 - 01/2003
6	Drug Therapy (Chemotherapy) 01/2019 - 01/2002
2	Aftercare (After-Treatment) 10/2012 - 12/2008
1	Topical Administration 10/2017